The University of Sydney
CANCER RESEARCH NETWORK UPDATE
CRN WEBSITE
FEBRUARY 2013
MESSAGE FROM THE CRN CHAIR
A big year ahead for the CRN
A belated welcome to 2013! I hope you had a good break and are surviving the grant season. 

2013 is shaping up to be a busy one for the CRN, starting with the formation of the new CRN Council, which will advise the University on cancer research strategy, development and investment. Voting registration closes this Monday 18 Feb, with voting for elected Council members opening shortly thereafter.
Dear members,

A belated welcome to 2013! I hope you had a good break and are surviving the grant season. 

2013 is shaping up to be a busy one for the CRN, starting with the formation of the new CRN Council, which will advise the University on cancer research strategy, development and investment. Voting registration closes this Monday 18 Feb, with voting for elected Council members opening shortly thereafter.

The Wills Review of Health and Medical Research at Sydney will soon report its recommendations, and fostering major multidisciplinary efforts have been a key focus of its work so far.

Our Special Interest Groups (SIG) are forging ahead with Breast Cancer and Comparative Oncology having added new momentum in 2012, with our longer established Metabolism & Microenvironment and Health Data Linkage groups also very active.

Some of their plans are highlighted below. If you’d like to join any of these groups, please email Merilyn Heuschkel (merilyn.heuschkel@sydney.edu.au)

Encouraging and supporting the next generation of cancer researchers is a key priority of the CRN. The annual Postgraduate Cancer Research Symposium has become a very successful flagship event. We’ll be hosting the Symposium in November, and it would be great to see all our postgraduate students and supervisors there this year. The CRN Postgraduate Student Travel Grants program will also be held again in 2013. 

Planning for the 2014 Sydney Cancer Conference is under way and we are calling for enthusiastic people to join the Organising Committee. Please read on for more details.

Might your research be enhanced by access to health linkage data? Remember that the CRN supports a University subscription to CHeReL, the Centre for Health Record Linkage, giving our researchers discounted access to health linkage data.

The CRN was established to foster collaboration and communication between cancer researchers, and to raise your profile in the University. Please get involved with the Network in 2013. Let us know about your successes, join or establish a SIG, inform the rest of us about your upcoming events. Let us know what you need from the Network.

Please also promote CRN membership to your colleagues: our influence as a community of researchers depends on a strong, visible and active CRN membership. Joining takes just a couple of minutes.

Good luck in all of your research and other endeavours throughout 2013.

Prof Graham Mann
Chair, University of Sydney Cancer Research Network 
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SPECIAL INTEREST GROUPS
 BCSIG    |  
Breast Cancer SIG
In the last 10 months the BCSIG has evolved from an idea, proposed by Prof Graham Mann, to being one of the largest and most vibrant Cancer Research Network Special Interest Groups.  The next 12 months is positioned to be just as productive as we work towards providing our 102 members and affiliates, further opportunities for cross-disciplinary dialogue and collaboration in breast cancer research.
In the last 10 months the BCSIG has evolved from an idea, proposed by Prof Graham Mann, to being one of the largest and most vibrant Cancer Research Network Special Interest Groups.  The next 12 months is positioned to be just as productive as we work towards providing our 102 members and affiliates, further opportunities for cross-disciplinary dialogue and collaboration in breast cancer research.

The survey conducted at the BCSIG inaugural Seminar held on 21 November 2012 gave insight into who our members are and what members want from this special interest group. We learned that while a majority of the poll participants were happy with the ‘theme’ in which they were allocated, more than half said that they cross over more than one ‘theme’. We also learned that a majority are interested in attending two BCSIG seminars per year.

In 2013, we will be running two seminars: one on 23 May and another in October.  Details about these events will soon be available. We are in the process of completing a NBCF ThinkTank application to support us in organizing the October seminar which we envision to be a key event for breast cancer research at the University of Sydney. We will update you on developments.

Finally, on behalf of the Steering Committee, I would like to welcome to the executive, Prof Peter Lay (representing the Biology and Genetics theme), Ms Gai Grayson (consumer representative), and Mr Zechariah Marting (student representative). 

We at the Steering Committee welcome your ideas for the BCSIG and this newsletter. Please email your comments and suggestions to bcsig@sydney.edu.au

Best wishes,
Prof Patrick  C Brennan, Chair BCSIG
 ECR REP    |  
BCSIG seeking an ECR representative
The BCSIG is seeking an enthusiastic early career researcher to join the BCSIG Steering Committee. The ECR representative must have been awarded a PhD or equivalent research doctorate within the last five years, and will be expected to attend BCSIG Steering Committee meetings (held every 2-3 months) and BCSIG events (2-3 each year).
The Breast Cancer SIG (BCSIG) is seeking an enthusiastic early career researcher (ECR) to join the BCSIG Steering Committee. The ECR representative must have been awarded a PhD or equivalent research doctorate within the last five years, and will be expected to attend BCSIG Steering Committee meetings (held every 2-3 months) and BCSIG events (2-3 each year).

In cooperation with the BCSIG Steering Committee and BCSIG Chair (Prof Patrick Brennan), he or she will:

  • facilitate early career researcher interests through the identification of issues and activities of importance to ECRs carrying out breast cancer research;
  • work with the Steering Committee to develop networking, mentoring and collaborative opportunities for early career breast cancer researchers;
  • contribute to the activities of the BCSIG with special emphasis on representing the interests of early career members.
To self-nominate, please email the following information to Merilyn Heuschkel (merilyn.heuschkel@sydney.edu.au) by 5pm on Wednesday, 27 February 2013:

  • Name:
  • Affiliation:
  • A paragraph describing the nature of the nominee’s research (approx. 150 words):
  • A paragraph describing how he or she would contribute to the Breast Cancer Special Interest Group (approx. 200 words)
*The nominee must be a member of the Cancer Research Network and currently undertaking research focusing on breast cancer.

The BCSIG ECR representative will be selected by the BCSIG Chair, Prof Patrick Brennan, and members of the Steering Committee. The representative will serve a one year term and may be re-elected for a further year.

If you have any queries, please contact Merilyn Heuschkel (merilyn.heuschkel@sydney.edu.au).
 CO-SIG    |  
Comparative Oncology SIG
To kick-off 2013, the CO-SIG will be hosting a special lecture by Dr Tony Papenfuss from The Walter and Eliza Hall Institute of Medical Research on 20 March.
To kick-off 2013, the CO-SIG will be hosting a special lecture by Dr Tony Papenfuss from The Walter and Eliza Hall Institute of Medical Research:

“Sequencing the Tassie devil facial tumour and making sense of it”
Date: Wednesday, 20 March 2013
Time: 5.00–6.30pm (presentation from 5.00pm, light supper from 6.00pm)
Venue: Conference Room, Darlington Centre, The University of Sydney
RSVP: By 11 March 2013 to merilyn.heuschkel@sydney.edu.au
 
Dr Tony Papenfuss’s research interests include:
  • Analysis of next generation sequence data in cancer
  • Methods for analysis of structural variation in cancer genomes
  • Next generation sequencing in malaria
  • Computational comparative genomics
  • Sensitive genomic sequence search techniques using hidden Markov models
  • Tasmanian devil facial tumour disease
 M&M SIG    |  
Metabolism & Microenvironment SIG
Happy New Year to you all. I’d like to welcome back all M&M SIG members, including those who joined after our meeting in June 2012. We aim to be an interdisciplinary group with broad membership and representation, to encourage interactions between USyd researchers who might not meet otherwise.
Happy New Year to you all. I’d like to welcome back all M&M SIG members, including those who joined after our meeting in June 2012. We aim to be an interdisciplinary group with broad membership and representation, to encourage interactions between USyd researchers who might not meet otherwise.

Planning of events for this year is underway, and we’re keen to get your input. We’re planning to hold a seminar in May or June, and would like to invite an interstate speaker as a focal point, with some USyd presentations as well. If you have suggestions of external speakers to invite, or would like to nominate yourself or a team member, please let us know. We’re particularly keen to showcase research by postgraduate students and ECRs, so tell us about your research, and we’ll make sure that you can tell others about it as well. 

We’re always looking for new members, so please also forward this e-mail to any new students, postdocs and staff members that you know with microenvironment and/or metabolism interests in cancer. Anyone is welcome to email Merilyn Heuschkel (merilyn.heuschkel@sydney.edu.au) to join. If you have ideas about other activities that the M&M SIG could undertake, please let us know as well.

Looking forward to hearing from you.

Best wishes,
A/Prof Jennifer Byrne, Chair M&M SIG

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SYDNEY CANCER CONFERENCE 2014
 SCC2014    |  
Join the Organising Committee
The Cancer Research Network invites nominations for SCC2014 Organising Committee member positions. SCC2014 will be held from 16-18 July 2014 in the New Law Building at the University of Sydney.
The Cancer Research Network invites nominations for SCC2014 Organising Committee member positions. SCC2014 will be held from 16-18 July 2014 in the New Law Building at the University of Sydney.

The Network seeks a balanced committee of enthusiastic people that successfully reflects the geographic and disciplinary breadth of the University's cancer researchers. 

Committee members will be required to:

  • Plan and organise SCC2014 (under the guidance of the Chair);
  • Attend and contribute to regular meetings throughout 2013/2014; and
  • Attend SCC2014.
Administrative and management support will be provided by the Cancer Research Network Executive Officer.

We encourage and welcome any Network member's self-nomination for committee service.  

To submit a nomination, please complete the online form by COB on Thursday, 28 February 2013.

The Cancer Research Network Management Committee will assess all nominations and select the Organising Committee. The term of membership is approximately 18 months, commencing early 2013.  

If you require any further information, please contact Merilyn Heuschkel by email or on 9114 1943.
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NEWS
University well represented in Cure Cancer grants
A group of 10 University of Sydney and affiliated medical institute cancer researchers have won a share in a record $3.2 million in grants awarded by the Cure Cancer Australia Foundation. Read more
New cancer consumer research paper published
Carla Saunders and Sally Crossing recently published a paper which aimed to identify the research needs and priorities of Australian cancer consumers. Read more
Informing women on breast cancer overdiagnosis
In a study exploring women's responses to being told about overdiagnosis in breast cancer screening, most women felt the information was important and could enable them to make choices. Read more
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EVENTS
 CONFERENCE    |  
International Society for Biological and Environmental Repositories Annual Meeting
Date: 5 – 9 May 2013
Location: Sydney Convention & Exhibition Centre
More information: Visit the Meeting website
 LECTURE    |  
Real-time tracking of cell cycle progression in melanoma and its implications for the ‘real world’
Speaker: Dr Nikolas Haass, Associate Faculty, Immune Imaging, Centenary Institute
Time and date: 12 noon, Thursday 21 February 2013
Venue: Centenary Institute Lecture Theatre, Level 6, Building 93, Royal Prince Alfred Hospital Grounds
Registration: Not required
Host: Centenary Institute
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CONTENTS
Message from the CRN Chair
Special Interest Groups
Sydney Cancer Conference 2014
News
Events
Member profile
Postgraduate profile
Funding opportunities
MEMBER PROFILE
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ARC Future Fellow A/Prof Deborah Marsh heads the Functional Genomics Laboratory in the Hormones and Cancer Division at the Kolling Institute of Medical Research. She is currently funded by the NHMRC to investigate the role that certain hormones might play in the development of epithelial ovarian cancer.
ARC Future Fellow A/Prof Deborah Marsh heads the Functional Genomics Laboratory in the Hormones and Cancer Division at the Kolling Institute of Medical Research. She is currently funded by the NHMRC to investigate the role that certain hormones might play in the development of epithelial ovarian cancer. 

The interplay between gene mutations and chromatin modification, with specific interest in ubiquitination, is a developing research area in her laboratory. Newly awarded funding is allowing her group to explore the role of histone monoubiquitination in ovarian cancer. Student projects in her group include investigating microRNA as markers of ovarian cancer and how microRNA may be regulated in this malignancy, as well as the importance of specific microRNA – target gene interactions for the development of ovarian cancer.

A/Prof Marsh has a long term interest in the molecular nature of familial cancer syndromes, with particular recent focus on the tumour suppressor CDC73 that is mutated in the germline of patients with Hyperparathyroidism Jaw Tumour syndrome, as well as somatically mutated in sporadic parathyroid cancer. While rare, studies of CDC73 mutations have shed important insights into the role of a key transcriptional complex, the human PAF1 complex, in cancer. Her research in this field has led to significant changes in the diagnosis of parathyroid cancer that have been widely adopted.
POSTGRADUATE PROFILE
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Belinda Wright is currently completing her PhD in the Faculty of Veterinary Sciences.
The Tasmanian devil is facing extinction in the wild due to a rare form of transmissible cancer- devil facial tumour disease (DFTD). The disease dynamics and relative isolation of the species within Tasmania has meant that DFTD has swept through the devil population rapidly and has already decimated the eastern populations of devils. However, as the disease has spread west there has been some slowing of disease progression, most likely due to the tumour evolving less aggressive forms.

Belinda Wright is currently completing her PhD in the Faculty of Veterinary Sciences and her research is focused on discovering whether any genetic differences in the western populations of devils could be influencing this slowed disease progression. She is also designing a genome-wide genotyping assay to be used to assess genetic diversity in the captive population of devils. Once the disease has been eradicated or controlled in the wild these ‘insurance’ devils can be reintroduced though they must maintain a high degree of wild genetic diversity in order to establish viable populations.
FUNDING OPPORTUNITIES
Future fellowships
Australian Research Council
Overseas travel fellowships
Australian Research Council
GAP1 unique prostate cancer tissue microarray project
Prostate Cancer Foundation of Australia
Aboriginal and Torres Strait Islander fellowships
NHMRC
Part-time employment fellowships
NHMRC
Industry career development fellowships
NHMRC
Population health career development fellowships
NHMRC
Discovery projects
Australian Research Council
Clinical career development fellowships
NHMRC
Prime Minister's prize for science
Australian Department of Industry, Innovation, Science, Research and Tertiary Education
Research project grants
Cancer Council NSW
Priority-driven young investigator project grants
Cancer Australia and other funders
Priority-driven collaborative cancer standard research grants
Cancer Australia and other funders
Project grants
NHMRC
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